By Jacob Robbins (auth.), Ragnar Ekholm, Leonard D. Kohn, Seymour H. Wollman (eds.)
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The twelve papers during this assortment grew out of the workshop on "Eco nomic Evolution, studying, and Complexity" held on the collage of Augsburg, Augsburg, Germany on could 23-25, 1997. The Augsburg workshop used to be the second one of 2 occasions within the Euroconference sequence on Evolutionary Economics, the 1st of which was once held in Athens, Greece in September 1993.
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Extra info for Control of the Thyroid Gland: Regulation of Its Normal Function and Growth
165 THYROID STIMULATING HORMONE: STRUCTURE AND FUNCTION 47 analysis of tryptic fragments of free a-subunits showed two main 3H-mannose-labeled peaks at fractions 66 and 70 (Fig. 7a). Both of these tryptic peptides contained 3H-mannose-labeled N-linked oligosaccharides, but only the second peptide contained 14C-tyrosine. This allowed the identification of these two tryptic fragments as the peptides bearing the oligosaccharide units linked to Asn 56 and Asn 82 , respectively. Analogously, HPLC analysis of the tryptic peptides of TSH revealed three main 3H-mannose-labeled peaks (Fig.
Schematic pathway of oligosaccharide processing on newly synthesized glycoproteins. The reactions are catalyzed by the following enzymes: (1) oligosaccharyltransferase, (2) a-glucosidase I, (3) a-glucosidase 11, (4) ER al,2-mannosidase, (I) N-acetylglucosaminylphosphotransferase, (11) N-acetylglucosamine-I-phosphodiester a-N-acetylglucosaminidase, (5) Golgi a-mannosidase I, (6) N-acetylglucosaminyltransferase I, (7) Golgi a-mannosidase 11, (8) N-acetylglucosaminyltransferase 11, (9) fucosyltransferase, (10) galactosyltransferase, (11) sialyltransferase.
127 The physiological relevance of such observations remains uncertain. POSTTRANSLATIONAL PROCESSING OF TSH The outstanding feature of the glycoprotein hormones is their relatively high carbohydrate content; the Q- and ß-subunits of TSH are approximately 21% and 12% carbohydrate by weight, respectively. In addition to the novel information gleaned by techniques of molecular biology, as reviewed in prior sections, any serious discussion of TSH must review how the oligosaccharides are added to the subunit precursors and how they are processed posttranslationally.
Control of the Thyroid Gland: Regulation of Its Normal Function and Growth by Jacob Robbins (auth.), Ragnar Ekholm, Leonard D. Kohn, Seymour H. Wollman (eds.)