By Hans-Joachim Knölker (Eds.)
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29. Murray, L. ; Lim, T. ; Hooper, J. N. ; Capon, R. J. Aust. J. Chem. 1995, 48, 2053–2058. 30. Capon, R. ; Murray, L. ; Sim, A. T. ; Rostas, J. A. ; Butler, M. ; Carroll, A. R. J. Nat. Prod. 1998, 61, 660–662. 31. ; Cho, K. ; Rho, J. ; Sim, C. J. J. Nat. Prod. 1999, 62, 647–649. 32. ; Sim, C. ; Im, K. ; Jung, J. H. J. Nat. Prod. 2005, 68, 711–715. 33. ; Sim, C. ; Shin, J. Biol. Pharm. Bull. 2006, 29, 570–573. 34. Morris, S. ; Andersen, R. J. Can. J. Chem. 1989, 67, 677–681. 35. Morris, S. ; Andersen, R.
Similar to the sceptrin reaction conditions) and the second heating to 150 C in methanol. 19 Cyclobutyl-containing bisindoles 206 and 207. Br 54 Clinton G. L. Veale and Michael T. 126 (a) H2O, 195 C, m-wave, 1 min. light on biosynthesis of the dictazolines. Dai et al. 125 Dictazole A (206) was found to be an inhibitor of the aspartic protease BACE1, which is believed to be involved in Alzheimer’s pathology. Dictazole A inhibited BACE1-mediated cleavage of amyloid precursor protein at an IC50 of 50 mg/mL.
Org. Chem. 1988, 53, 5446–5453. 26. ; Cho, H. ; Jung, J. H. J. Nat. Prod. 2007, 70, 2–8. 27. Oh, K. ; Sim, C. ; Shin, J. Bioorg. Med. Chem. Lett. 2005, 15, 4927–4931. 28. Phife, D. ; Ramos, R. ; Gunasekera, S. ; Pachter, J. ; Coval, S. J. Bioorg. Med. Chem. Lett. 1996, 6, 2103–2106. 29. Murray, L. ; Lim, T. ; Hooper, J. N. ; Capon, R. J. Aust. J. Chem. 1995, 48, 2053–2058. 30. Capon, R. ; Murray, L. ; Sim, A. T. ; Rostas, J. A. ; Butler, M. ; Carroll, A. R. J. Nat. Prod. 1998, 61, 660–662. 31. ; Cho, K.
Chemistry and Biology by Hans-Joachim Knölker (Eds.)