By Dick Hoekstra (Eds.)
Not easy and provocative overviews are offered in quantity forty of Current subject matters in Membranes . issues on cellphone lipids differ from easy subject matters akin to biosynthesis and membrane distribution to the position of lipids in intracellular signaling and membrane stream. This unmarried quantity additionally highlights the jobs of lipids in eukaryotic cells and discusses association of lipids in microdomains.
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26 Ben Roelofsen and Jos A. F. Op den Kamp 2. Because of the high dilution factors that have been applied for ghost preparation in both these studies, some of the membrane skeletal proteins might have been removed (Clark and Ralston, 1990), or their interactions with the bilayer transiently disturbed. In conjunction with the loss of ATP that accompanies the lysis of the cells, the requirements for changes in phospholipid asymmetry seem to have been fulfilled again. Note, however, that the study by Schrier et al.
However, whether such a situation can ever be reached can be strongly doubted. , 1987a). , 1984). Hence, a shift of aminophospholipids from inner to outer monolayer, as a consequence of whatever conditions, can be compensated for only by a shift of some of the PC in the opposite direction. In principle, two possibilities must be considered for the ultimate (passive) redistribution of the three glycerophospholipids that can occur under conditions of a complete failure of the mechanisms that normally generate and maintain phospholipid asymmetry (Fig.
At the same time point, the distribution of the labeled PE seems to reach an equilibrium at which less than the normal 80% of this lipid is present in the inner leaflet. H/j ,I 5 10 15 20 25 TIME [Hours] AFTER INSERTION OF RADIOLABELED P - LIPIDS FIGURE 1 Transbilayer migration of radiolabeled glycerophospholipids in control (kfr) and diamide-treated (right) human erythrocytes at 37°C. Trace amounts of radiolabeled phospholipids were inserted into the outer membrane leaflet of intact cells using nonspecific lipid transfer protein from bovine liver.
Cell Lipids by Dick Hoekstra (Eds.)