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Download e-book for kindle: Cell Adhesion Molecules in Human Transplantation (Medical by Gustav Steinhoff

By Gustav Steinhoff

ISBN-10: 0585408564

ISBN-13: 9780585408569

ISBN-10: 1570595178

ISBN-13: 9781570595172

Scientific institution Hannover, Germany. offers a huge survey approximately most recent learn in expression and induction of assorted intercellular adhesion molecules in scientific kidney, liver, middle, and lung transplantation. For researchers.

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Additional resources for Cell Adhesion Molecules in Human Transplantation (Medical Intelligence Unit)

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Expression of integrins in normal and rejecting kidney nd – – – nd Resident Interstitial Leukocytes +/– + – – ++/– T Cells +/– + – – ++/– Macrophages Inflammatory Infiltration During Rejection 42 Cell Adhesion Molecules in Organ Transplantation – – – – – – – – – – – – – – – – – – – – ++ ++ – – – – – – ++1 ++1 – – – – – – ++1 ++1 1 basal localization 2 Intimal, medial and endothelial staining 3 Parietal epithelium of Bowman’s capsule and basal and lateral surface of podocytes nd, not determined; +/–, indicates differences in the level of staining VLA-6 Normal Rejection LFA-1 Normal Rejection MAC-1 Normal Rejection p150,95 Normal Rejection – – – – – – nd nd – – – – – – nd nd – – – – – – ++ ++ ++ +++ +++ nd – – +++ – +++ +++ +++ – MHC Antigen and CAM Expression in Clinical Renal Transplantation 43 44 Cell Adhesion Molecules in Organ Transplantation VLA-2.

In the liver sinusoid this reaction occurs in two ways, as sinusoidal endothelia and Kupffer cells possess both MHC class II and CD4 receptors. A reversible binding of MHC to TCR may allow a fluent contact to antigen peptides. The binding of VLA-4 to VCAM-1 and of LFA-1/MAC-1 to ICAM-1 18 Cell Adhesion Molecules in Organ Transplantation Fig. 3. Late phase of inflammation. This event is characterized by the activation of leukocytes and their definitive/firm adhesion to activated endothelial cells.

The molecules mediating contact function between cells form the basis for processes as cellular morphology, histogenesis, cellular differentiation and migration. 1. Classification of the molecules of the human major histocompatibility complex (MHC) Class I Class II Gene region A,B,C,E,F,G,J,H DR,DQ,DP,DN,DO,DM,DV,DX,DZ Molecules HLA-A,B,C HLA-DR,DQ,DP Structure 44,000 Dalton heavy chain +/- 34,000 Dalton α chain 12,000 Dalton β2-microglobulin +/- 29,000 Dalton β chain restriction of CD-8+ zytotoxic T lymphocytes Restriction of CD-4 positive helper T lymphocytes antigen presentation antigen presentation HLA-A,B,C HLA-DR,DQ,DP Function Polymorphism and infiltration by leukocytes and platelets are mainly mediated by receptor-ligand interactions with target cells (cell-cell) and extracellular matrix proteins (cell-matrix).

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Cell Adhesion Molecules in Human Transplantation (Medical Intelligence Unit) by Gustav Steinhoff


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