By B. Åblad (auth.), Professor Dr. Erich Lang, Dr. Fritz Sörgel, Dr. Lothar Blaha (eds.)
In conjunction with the 12th overseas Congress of Gerontology, the Carl-Korth Institute for Cardiovascular study geared up a world symposium on "Beta Blockers within the Elderly." It used to be the goal of the clinical Committee that in this symposium we might speak about the explicit difficulties and healing implications bobbing up while aged humans need to be handled with beta-blocking brokers. specific emphasis used to be put on the unwanted side effects and the age established beneficial properties of beta-blocker treatment. Beta-blockers became validated within the remedy of either cardiovascular illnesses and neuropsychiatric issues. Their effectiveness in sufferers struggling with heart sickness, high blood pressure, and hyperkinetic cardiac syndromes has lengthy been confirmed. the advance of recent, selectively energetic beta-blockers has considerably diminished the variety of attainable unwanted effects, therefore improving healing protection. simply because unwanted side effects can't be eradicated, although, beta blockers were brought simply hesitantly into therapy of the aged. This booklet is the 1st wide-ranging survey of using beta blockers in aged sufferers. The articles contained herei- written through pharmacologists, cardiologists, activities physicians, neurologists, psychiatrists, and ophthalmologists - exhibit that complex age on my own doesn't contraindicate using beta-blockers and sympatholytic ingredients. additionally supplied are guidance for exam and resolution of in dications within the aged. either the symposium and the e-book of this quantity were kindly supported through Astra chemical substances, West Germany.
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Extra resources for Beta-Blockers in the Elderly
Since pretrial exclusions have not been detailed, it is impossible to generalize from these findings. The aim of the Copenhagen trial  was to study short- and long-term mortality as well as tolerance for alprenolol in elderly patients. Treatment was begun on admission to the coronary care unit, when patients were allocated randomly to treatment with intravenous alprenolol or placebo. Oral maintenance treatment ensued, and the patients were followed up for 58 Table 3. End-points in the G6teborg alprenolol trial Alprenolol Placebo 16 3 7 18 11 14 ------ ---~----~~--~-"-------- Nonfatal reinfarctions Sudden deaths Total number of deaths Table 4.
Bradycardia and postural hypotension were not found to be problems. Patients over the age of 70 years had the lowest incidence of withdrawals, but received the highest average daily dose of the combination agent (Table 2). There was little change in the serum values of potassium, glucose and uric acid during the 8-week study period. Atenolol and Chlorthalidone (Tenoretic) A hospital out-patient study of ate nolo I in combination with chlorthalidone has recently been described . This open, uncontrolled trial included 499 hypertensive patients over the age of 60 years (range 60-90 years).
Elimination Based on the fact that kidney function is greatly reduced in old age, one would expect the elimination of drugs that are eliminated predominantly unmetabolized via the kidneys, (i. , hydrophilic agents such as practolol, atenolol, nadolol, or sotalol, to be impaired in old people. As far as practolol and sotalol are concerned, this assumption has been confirmed by studies in the elderly. The half-life of metoprolol did not vary with age, or was somewhat shortened. However, the excretion of an active metabolite of metoprolol was impaired.
Beta-Blockers in the Elderly by B. Åblad (auth.), Professor Dr. Erich Lang, Dr. Fritz Sörgel, Dr. Lothar Blaha (eds.)