By David S. Goodsell
This publication will take an evidence-based method of present wisdom approximately biomolecules and their position in our lives, inviting readers to discover how we all know what we all know, and the way present gaps in wisdom may perhaps impact the way in which we method the data. Biomolecular technology is more and more very important in our way of life, influencing the alternatives we make approximately our nutrition, our overall healthiness, and our wellbeing. frequently, even if, information regarding biomolecular technological know-how is gifted as an inventory of immutable evidence, discouraging severe concept. The publication will introduce the elemental instruments of structural biology, provide real-life examples, and inspire serious thought of features of biology which are nonetheless no longer totally understood.
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Extra resources for Atomic Evidence: Seeing the Molecular Basis of Life
Another great hope, building directly on our knowledge of the genetic code, is gene therapy: the ability to replace faulty genes in the cells of a patient, curing genetic diseases at their source. Once we’ve identified the problem, synthesizing the corrected DNA is fairly straightforward, but the tricky part of this is finding a way to get the genes into the afflicted cells. Today, this is primarily done by creating an engineered virus, such as adenovirus (. Fig. 7), that infects the cell and inserts the therapeutic DNA in the process.
1007/978-3-319-32510-1_8 8 52 8 Chapter 8 · How Evolution Shapes Proteins Just yesterday, I was walking to my car from the lab and I found a stick insect on the sidewalk. I picked him up to return him back to the greenery. As I was coaxing him onto my hand, he suddenly folded up his long, spindly legs and turned into, well, a stick. Evolution is an odd, meandering process, which often produces unexpectedly magical results. There’s much evidence for this in our everyday world: you only need to look around.
We only need to look at our most 53 Chapter 8 · How Evolution Shapes Proteins familiar protein, hemoglobin, to see an example of this. Our genome includes several very similar proteins, presumably all created by duplication from an original ancestor protein. These include the two chains of hemoglobin, a few different forms of hemoglobin optimized for use before birth, myoglobin, and two more recently discovered forms with as-yet unknown function: cytoglobin and neuroglobin (. Fig. 1). The ease of gene duplication has led to a modular approach to the evolution of proteins.
Atomic Evidence: Seeing the Molecular Basis of Life by David S. Goodsell