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New PDF release: Antipsychotics

By Susan A. Minchin, John G. Csernansky (auth.), Professor John G. Csernansky (eds.)

ISBN-10: 3642610072

ISBN-13: 9783642610073

ISBN-10: 3642646530

ISBN-13: 9783642646539

Antipsychotic medicinal drugs have been first came upon in 1953, and never because the past due Seventies has the guide of Experimental Pharmacology taken up this subject. a brand new remedy of this subject will be due less than any situations; notwithstanding, this is often now really actual, given that awesome growth has been made on numerous fronts in furthering our figuring out of the mechanisms of antipsychotic drug motion. First, we've got realized that schizophrenia is an affliction with particu­ lar neuroanatomical abnormalities, a lot of which recommend that the ailment is because of error in neurodevelopment. those findings have helped to shape a context for knowing neurochemical aberrations within the sickness and recommend new methods for pharmacological remedy. Propelled ahead via speedy advances in neurochemical anatomy, present pathophysiological hypotheses of schizophrenia and antipsychotic drug motion have taken at the visual appeal of complicated electric circuit diagrams. moment, molecular biology reports have now printed that there's a multiplicity of dopamine receptors (i. e. , D , DZshort' j DZlong, D , D , and D ), a few of which can turn into totally new goals for three four s antipsychotic drug motion. paradoxically, the improvement of substances which are selec­ tive for those receptors and that may be used to enquire their functionality lags at the back of; but the invention of those new receptors deals remarkable opportu­ nities for constructing medications with stronger efficacy and less part effects.

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Ann Med Psychol 110:267-273 Deniker P (1970) Introduction of neuroleptic chemotherapy into psychiatry. In: Ayd FJ, Blackwell B (eds) Discoveries in biological psychiatry. Lippincott, Philadelphia Deutch A Y, Moghaddam B, Innis RB, Krystal JH, Aghajanian GK, Bunney BS, Charney DS (1991) Mechanisms of action of atypical antipsychotic drugs. Implications for novel therapeutic strategies for schizophrenia. Schizophr Res 4:121-156 Driscoll MS, Rother MJ, Grant-Kels JM, Hale MS (1993) Delusional parasitosis: a dermatological, psychiatric, and pharmacologic approach.

Chim Ther 7:493-502 Baldessarini RJ (1980) Drugs and the treatment of psychiatric disorders. In: Gilman AG, Goodman LS, Gilman A (eds) Goodman and Gilman's the pharmaecological basis of therapeutics, 6th ed. MacMillan, New York, pp 391-418 Baldessarini RJ (1985) Chemotherapy in psychiatry. Principles and practice. Harvard University Press, Cambridge Biel JH, Bopp B, Mitchell BD (1978) Chemistry and structure-activity relationships of psychotropic drugs. In: Clark WG, del Guidice J (eds) Principles of psychopharmacology, 2nd edn.

J Clin PsychopharmacoI6(5):257-273 Peroutka SJ, Snyder SH (1980) Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histaminic receptors to clinical potency. Am J Psychiatry 137:1518-1522 Perry PJ, Alexander B, Liskow BI (1988) Psychotropic drug handbook. Harvey Whitney Books, Cincinnati Petracek FJ, Biel JH, Bopp B, Mitchell BD (1978) Chemistry and structure-activity relationships of psychotropic drugs. In: Clark WG, del Giudice J (eds) Principles of Psychopharmacology.

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Antipsychotics by Susan A. Minchin, John G. Csernansky (auth.), Professor John G. Csernansky (eds.)

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