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Animal Models for the Study of Human Disease by P. Michael Conn PDF

By P. Michael Conn

ISBN-10: 0124158943

ISBN-13: 9780124158948

Animal versions for the research of Human Disease identifies vital animal versions and assesses the benefits and downsides of every version for the examine of human disorder. The first part addresses tips to find assets, animal choices, animal ethics and comparable matters, a lot wanted info for researchers around the organic sciences and biomedicine.The subsequent sections of the paintings deals types for disease-oriented themes, together with cardiac and pulmonary illnesses, getting older, infectious illnesses, weight problems, diabetes, neurological illnesses, joint ailments, visible issues, melanoma, high blood pressure, genetic ailments, and illnesses of abuse.

  • Organized by means of disorder orientation for ease of searchability
  • Provides details on finding assets, animal possible choices and animal ethics
  • Covers a wide variety of animal versions utilized in study for human disease

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Extra resources for Animal Models for the Study of Human Disease

Sample text

However, interpretations of reduction and replacement as aims independent of minimization of pain or distress are typically applied to all animal research. It is supposed to be ethically obligatory to use fewer or no animals even if animals that are used experience no pain or distress, have a much better life than they would in natural environments, are “happy” when used in research, or are not killed during or after research. The Need for Clarity and Argument Regarding the 3Rs It would be useful for the field of animal research ethics to consider in depth how the 3Rs should be defined and what their goal or goals should be.

C. x2131 et seq. (2006). Health Research Extension Act of 1985. C. x 289d (2006). Animal Welfare Act Regulations. R. Ch. 1. 1 et seq. (2011). 34. American Veterinary Medical Association. AVMA guidelines for the euthanasia of animals: 2013 edition from, https://www. pdf. 35. Institute for Laboratory Animal Research. The psychological wellbeing of nonhuman primates. Washington, DC: National Academies Press; 1998. 36. National Institute of Mental Health. Methods and welfare considerations in behavioral research with animals: Report of a National Institutes of Health workshop.

P1. Approach all phases and aspects of an animal research project with the aim of making the project ethically as well as scientifically sound. The wisdom of this guideline is demonstrated by all the reasons, discussed above, why it is critically important for investigators to conduct ethical animal research. Particularly good times to review the ethical soundness of a project are when one is already thinking about the project as a whole; for many investigators this will be during the preparation of a grant proposal and of an IACUC animal-use application.

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