By Cris dos Remedios, Deepak Chhabra
This quantity, written by means of specialists within the box, is the 1st to house the connection among human illness and the actin cytoskeleton. It offers overviews of actin and chosen actin-binding proteins, after which makes a speciality of ailments that contain those proteins. particular chapters care for actin, cofilin, profilin, gelsolin and thymosin ¾4. different chapters talk about the jobs of a number of actin-binding proteins in melanoma and metastasis, leukocyte problems, and center failure, and there's a bankruptcy that describes how intracellular pathogens use the host actin cytoskeleton. This seminal quantity is meant for researchers, clinicians, physicians, and graduate scholars within the fields of biochemistry, cellphone biology, microbiology, immunology, and genetics.
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Additional resources for Actin-Binding Proteins and Disease
Actin mutants causing changed muscle kinetics. Nature 348, 440–442. Durling, H. , Lochmuller, H. and Laing, N. G. 2002. De novo missense mutation in a constitutively expressed exon of the slow alpha-tropomyosin gene TPM3 associated with an atypical, sporadic case of nemaline myopathy. Neuromuscul. Dis. 12, 947–951. Elfenbein, J. , Fisher, R. , Morrell, R. , Friedman, T. B. and Friderici, K. 2001. Audiological aspects of the search for DFNA20: A gene causing late-onset, progressive sensoneural hearing loss.
1979. Nuclear actin bundles in Amoeba, Dictyostelium and human HeLa cells induced by dimethyl sulfoxide. Exp. Cell Res. 120, 451–455. Gillespie, P. , Dumont, R. A. and Kachar, B. 2005. Have we found the tip link, a trasnsduction channel and gating spring of the hair cell? Curr. Opin. Neurobiol. 15, 389–396. Hennessey, E. , Drummond, D. R. and Sparrow, J. C. 1991. Post-translational processing of the amino terminus affects actin function. Eur. J. Biochem. 197, 345–352. Hennessey, E. , Drummond, D.
Why some mutations are specific to CFTD or nemaline myopathy, and others cause both, remains an issue that might explain the ontogeny of both diseases. Molecular Effects of ACTA1 Myopathy Mutations What functions of actin are affected by these congenital ACTA1 myopathy mutations? The fact that mutations within ACTA1 can produce different phenotypes – nemaline rods, actinopathy, intranuclear rods, and CFTD suggests that these might arise because different mutants affect the interaction of actin with different sarcomeric proteins.
Actin-Binding Proteins and Disease by Cris dos Remedios, Deepak Chhabra